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Cardiothoracic and Vascular Surgery

Anticoagulation Management and Reversal

Prothrombin complex concentrates versus fresh frozen plasma for warfarin reversal. A systematic review and meta-analysis. (opens new window)

Chai-Adisaksopha C, Hillis C, Siegal DM, Movilla R, Heddle N, Iorio A, Crowther M.

Source‎: Thromb Haemost 2016;116(5):879-90.

Indexed‎: PubMed 27488143

DOI‎: 10.1160/TH16-04-0266

https://www.ncbi.nlm.nih.gov/pubmed/27488143 (opens new window)

Reversal of warfarin: case-based practice recommendations. (opens new window)

Garcia DA, Crowther MA.

Source‎: Circulation 2012;125(23):2944-7.

Indexed‎: PubMed 22689931

DOI‎: 10.1161/CIRCULATIONAHA.111.081489

https://www.ncbi.nlm.nih.gov/pubmed/22689931 (opens new window)

Stopping antiplatelet medication before coronary artery bypass graft surgery: is there an optimal timing to minimize bleeding? (opens new window)

Gielen CL, Bruggemans EF, Stijnen T, Eikenboom J, Tavilla G, Brand A, Klautz RJ.

Source‎: Eur J Cardiothorac Surg 2015;48(4):e64-70.

Indexed‎: PubMed 26248820

DOI‎: 10.1093/ejcts/ezv269

https://www.ncbi.nlm.nih.gov/pubmed/26248820 (opens new window)

Is a fully heparin-bonded cardiopulmonary bypass circuit superior to a standard cardiopulmonary bypass circuit? (opens new window)

Mahmood S, Bilal H, Zaman M, Tang A.

Source‎: Interact Cardiovasc Thorac Surg 2012;14(4):406-14.

Indexed‎: PubMed 22228288

DOI‎: 10.1093/icvts/ivr124

https://www.ncbi.nlm.nih.gov/pubmed/22228288 (opens new window)

Heparin-bonded circuits versus nonheparin-bonded circuits: an evaluation of their effect on clinical outcomes. (opens new window)

Mangoush O, Purkayastha S, Haj-Yahia S, Kinross J, Hayward M, Bartolozzi F, Darzi A, Athanasiou T.

Source‎: Eur J Cardiothorac Surg 2007;31(6):1058-69.

Indexed‎: PubMed 17306555

DOI‎: 10.1016/j.ejcts.2007.01.029

https://www.ncbi.nlm.nih.gov/pubmed/17306555 (opens new window)

Heparin-coated extracorporeal circulation in combination with low dose systemic heparinization reduces early postoperative blood loss in cardiac surgery. (opens new window)

Mirow N, Zittermann A, Koertke H, Maleszka A, Knobl H, Coskun T, Kleesiek K, Koerfer R.

Source‎: J Cardiovasc Surg (Torino) 2008;49(2):277-84.

Indexed‎: PubMed 18431350

https://www.ncbi.nlm.nih.gov/pubmed/18431350 (opens new window)

Idarucizumab for dabigatran reversal. (opens new window)

Pollack CV Jr, Reilly PA, Eikelboom J, Glund S, Verhamme P, Bernstein RA, Dubiel R, Huisman MV, Hylek EM, Kamphuisen PW, Kreuzer J, Levy JH, Sellke FW, Stangier J, Steiner T, Wang B, Kam CW, Weitz JI.

Source‎: N Engl J Med 2015;373(6):511-20.

Indexed‎: PubMed 26095746

DOI‎: 10.1056/NEJMoa1502000

https://www.ncbi.nlm.nih.gov/pubmed/26095746 (opens new window)

Idarucizumab for dabigatran reversal - full cohort analysis. (opens new window)

Pollack CV Jr, Reilly PA, van Ryn J, Eikelboom JW, Glund S, Bernstein RA, Dubiel R, Huisman MV, Hylek EM, Kam CW, Kamphuisen PW, Kreuzer J, Levy JH, Royle G, Sellke FW, Stangier J, Steiner T, Verhamme P, Wang B, Young L, Weitz JI

Source‎: N Engl J Med 2017;377(5):431-41.

Indexed‎: PubMed 28693366

DOI‎: 10.1056/NEJMoa1707278

https://www.ncbi.nlm.nih.gov/pubmed/28693366 (opens new window)

Platelet mapping and desmopressin reversal of platelet inhibition during emergency carotid endarterectomy. (opens new window)

Ranucci M, Nano G, Pazzaglia A, Bianchi P, Casana R, Tealdi DG.

Source‎: J Cardiothorac Vasc Anesth 2007;21(6):851-4.

Indexed‎: PubMed 18068065

DOI‎: 10.1053/j.jvca.2007.05.009

https://www.ncbi.nlm.nih.gov/pubmed/18068065 (opens new window)

Efficacy and safety of a 4-factor prothrombin complex concentrate in patients on vitamin K antagonists presenting with major bleeding: a randomized, plasma-controlled, phase IIIb study. (opens new window)

Sarode R, Milling TJ Jr, Refaai MA, Mangione A, Schneider A, Durn BL, Goldstein JN.

Source‎: Circulation 2013;128(11):1234-43.

Indexed‎: PubMed 23935011

DOI‎: 10.1161/CIRCULATIONAHA.113.002283

https://www.ncbi.nlm.nih.gov/pubmed/23935011 (opens new window)

Protective effects of tranexamic acid on clopidogrel before coronary artery bypass grafting: a multicenter randomized trial. (opens new window)

Shi J, Ji H, Ren F, Wang G, Xu M, Xue Y, Chen M, Qi J, Li L.

Source‎: JAMA Surg 2013;148(6):538-47.

Indexed‎: PubMed 23426385

DOI‎: 10.1001/jamasurg.2013.1560

https://www.ncbi.nlm.nih.gov/pubmed/23426385 (opens new window)

Andexanet alfa for the reversal of Factor Xa inhibitor activity. (opens new window)

Siegal DM, Curnutte JT, Connolly SJ, Lu G, Conley PB, Wiens BL, Mathur VS, Castillo J, Bronson MD, Leeds JM, Mar FA, Gold A, Crowther MA.

Source‎: N Engl J Med 2015;373(25):2413-24.

Indexed‎: PubMed 26559317

DOI‎: 10.1056/NEJMoa1510991

https://www.ncbi.nlm.nih.gov/pubmed/26559317 (opens new window)

Recombinant factor VIIa (rFVIIa) and hemodialysis to manage massive dabigatran-associated postcardiac surgery bleeding. (opens new window)

Warkentin TE, Margetts P, Connolly SJ, Lamy A, Ricci C, Eikelboom JW.

Source‎: Blood 2012;119(9):2172-4.

Indexed‎: PubMed 22383791

DOI‎: 10.1182/blood-2011-11-393587

https://www.ncbi.nlm.nih.gov/pubmed/22383791 (opens new window)

Heparinized cardiopulmonary bypass circuits and low systemic anticoagulation: an analysis of nearly 6000 patients undergoing coronary artery bypass grafting. (opens new window)

Øvrum E, Tangen G, Tølløfsrud S, Skeie B, Ringdal MA, Istad R, Øystese R.

Source‎: J Thorac Cardiovasc Surg 2011;141(5):1145-9.

Indexed‎: PubMed 20709334

DOI‎: 10.1016/j.jtcvs.2010.07.003

https://www.ncbi.nlm.nih.gov/pubmed/20709334 (opens new window)