Skip to content

Cost-Effectiveness of Blood Transfusion Alternatives

Cardiothoracic and Vascular Surgery

The impact of a multidisciplinary blood conservation protocol on patient outcomes and cost after cardiac surgery. (opens new window)

Ad N, Holmes SD, Patel J, Shuman DJ, Massimiano PS, Choi E, Fitzgerald D, Halpin L, Fornaresio LM.

Source‎: J Thorac Cardiovasc Surg 2017;153(3):597-605.e1.

Indexed‎: PubMed 27938898

DOI‎: 10.1016/j.jtcvs.2016.10.083

https://www.ncbi.nlm.nih.gov/pubmed/27938898 (opens new window)

Costs of bleeds relating to acute coronary syndrome therapies. (opens new window)

Bufe A, Emile F, Drogoul L, Guindo Soldevila J, Giuseppe DP, Maddalena L, Janzon M, Brown RE.

Source‎: J Med Econ 2010;13(2):236-40.

Indexed‎: PubMed 20465368

DOI‎: 10.3111/13696998.2010.488882

https://www.ncbi.nlm.nih.gov/pubmed/20465368 (opens new window)

Preoperative anemia management program reduces blood transfusion in elective cardiac surgical patients, improving outcomes and decreasing hospital length of stay. (opens new window)

Cahill CM, Alhasson B, Blumberg N, Melvin A, Knight P, Gloff M, Robinson R, Akwaa F, Refaai MA.

Source‎: Transfusion 2021;61(9):2629-36.

Indexed‎: PubMed 34268778

DOI‎: 10.1111/trf.16564

https://www.ncbi.nlm.nih.gov/pubmed/34268778 (opens new window)

Recombinant factor VIIa (NovoSeven RT) use in high risk cardiac surgery. (opens new window)

Chapman AJ, Blount AL, Davis AT, Hooker RL.

Source‎: Eur J Cardiothorac Surg 2011;40(6):1314-8.

Indexed‎: PubMed 21601468

DOI‎: 10.1016/j.ejcts.2011.03.048

https://www.ncbi.nlm.nih.gov/pubmed/21601468 (opens new window)

Experience of a network of transfusion coordinators for blood conservation (Ontario Transfusion Coordinators [ONTraC]). (opens new window)

Freedman J, Luke K, Escobar M, Vernich L, Chiavetta JA.

Source‎: Transfusion 2008;48(2):237-50.

Indexed‎: PubMed 18005329

DOI‎: 10.1111/j.1537-2995.2007.01515.x

https://www.ncbi.nlm.nih.gov/pubmed/18005329 (opens new window)

Clinical effects of reverting from leukoreduced to nonleukoreduced blood in cardiac surgery. (opens new window)

Fung MK, Moore K, Ridenour M, Mook W, Triulzi DJ.

Source‎: Transfusion 2006;46(3):386-91.

Indexed‎: PubMed 16533280

DOI‎: 10.1111/j.1537-2995.2006.00733.x

https://www.ncbi.nlm.nih.gov/pubmed/16533280 (opens new window)

Treatment of refractory bleeding after cardiac operations with low-dose recombinant activated factor VII (NovoSeven®): a propensity score analysis. (opens new window)

Gelsomino S, Lorusso R, Romagnoli S, Bevilacqua S, De Cicco G, Billè G, Stefàno P, Gensini GF.

Source‎: Eur J Cardiothorac Surg 2008;33(1):64-71.

Indexed‎: PubMed 17996457

DOI‎: 10.1016/j.ejcts.2007.10.004

https://www.ncbi.nlm.nih.gov/pubmed/17996457 (opens new window)

The clinical and economic burden of significant bleeding during lung resection surgery: a retrospective matched cohort analysis of real-world data. (opens new window)

Ghosh SK, Roy S, Daskiran M, Yoo A, Li G, Fegelman EJ.

Source‎: J Med Econ 2016;19(11):1081-6.

Indexed‎: PubMed 27266753

DOI‎: 10.1080/13696998.2016.1199431

https://www.ncbi.nlm.nih.gov/pubmed/27266753 (opens new window)

How do we develop and implement a preoperative anemia clinic designed to improve perioperative outcomes and reduce cost? (opens new window)

Guinn NR, Guercio JR, Hopkins TJ, Grimsley A, Kurian DJ, Jimenez MI, Bolognesi MP, Schroeder R, Aronson S; Duke Perioperative Enhancement Team (POET).

Source‎: Transfusion 2016;56(2):297-303.

Indexed‎: PubMed 26592207

DOI‎: 10.1111/trf.13426

https://www.ncbi.nlm.nih.gov/pubmed/26592207 (opens new window)

Comprehensive multimodality blood conservation: 100 consecutive CABG operations without transfusion. (opens new window)

Helm RE, Rosengart TK, Gomez M, Klemperer JD, DeBois WJ, Velasco F, Gold JP, Altorki NK, Lang S, Thomas S, Isom OW, Krieger KH.

Source‎: Ann Thorac Surg 1998;65(1):125-36.

Indexed‎: PubMed 9456106

https://www.ncbi.nlm.nih.gov/pubmed/9456106 (opens new window)

Positive impact of retrograde autologous priming in adult patients undergoing cardiac surgery: a randomized clinical trial. (opens new window)

Hofmann B, Kaufmann C, Stiller M, Neitzel T, Wienke A, Silber RE, Treede H.

Source‎: J Cardiothorac Surg 2018;13(1):50.

Indexed‎: PubMed 29784004

DOI‎: 10.1186/s13019-018-0739-0

https://www.ncbi.nlm.nih.gov/pubmed/29784004 (opens new window)

Cost effectiveness of implementing ESC guidelines for treatment of iron deficiency in heart failure in the Nordic countries. (opens new window)

Hofmarcher T, Cabrales Alin D, Linde C.

Source‎: Scand Cardiovasc J 2018;52(6):348-55.

Indexed‎: PubMed 30457358

DOI‎: 10.1080/14017431.2018.1546894

https://www.ncbi.nlm.nih.gov/pubmed/30457358 (opens new window)

Economic evaluation of national patient blood management clinical guidelines in cardiac surgery. (opens new window)

Irving AH, Harris A, Petrie D, Higgins A, Smith JA, Tran L, Reid CM, McQuilten ZK.

Source‎: Value Health 2022;25(3):419-26.

Indexed‎: PubMed 35227454

DOI‎: 10.1016/j.jval.2021.07.014

https://www.ncbi.nlm.nih.gov/pubmed/35227454 (opens new window)

Blood product conservation is associated with improved outcomes and reduced costs after cardiac surgery. (opens new window)

LaPar DJ, Crosby IK, Ailawadi G, Ad N, Choi E, Spiess BD, Rich JB, Kasirajan V, Fonner E Jr, Kron IL, Speir AM; Investigators for the Virginia Cardiac Surgery Quality Initiative.

Source‎: J Thorac Cardiovasc Surg 2013;145(3):796-804.

Indexed‎: PubMed 23414992

DOI‎: 10.1016/j.jtcvs.2012.12.041

https://www.ncbi.nlm.nih.gov/pubmed/23414992 (opens new window)

Intraoperative cell salvage versus allogeneic transfusion during abdominal aortic surgery: clinical and financial outcomes. (opens new window)

Marković M, Davidović L, Savić N, Sindjelić R, Ille T, Dragas M.

Source‎: Vascular 2009;17(2):83-92.

Indexed‎: PubMed 19426638

DOI‎: 10.2310/6670.2009.00009

https://www.ncbi.nlm.nih.gov/pubmed/19426638 (opens new window)

Evaluation of a multilevel laboratory stewardship intervention targeted to cardiac and thoracic surgical services at an academic medical center. (opens new window)

Mathias PC, Khor S, Harris K, Wood SJ, Farjah F.

Source‎: Arch Pathol Lab Med 2023;147(8):957-63.

Indexed‎: PubMed 36287195

DOI‎: doi: 10.5858/arpa.2021-0593-OA.

https://www.ncbi.nlm.nih.gov/pubmed/36287195 (opens new window)

Increased mortality, postoperative morbidity, and cost after red blood cell transfusion in patients having cardiac surgery. (opens new window)

Murphy GJ, Reeves BC, Rogers CA, Rizvi SI, Culliford L, Angelini GD.

Source‎: Circulation 2007;116(22):2544-52.

Indexed‎: PubMed 17998460

DOI‎: 10.1161/CIRCULATIONAHA.107.698977

https://www.ncbi.nlm.nih.gov/pubmed/17998460 (opens new window)

Safety, efficacy, and cost of intraoperative cell salvage and autotransfusion after off-pump coronary artery bypass surgery: A randomized trial. (opens new window)

Murphy GJ, Rogers CS, Lansdowne WB, Channon I, Alwair H, Cohen A, Caputo M, Angelini GD.

Source‎: J Thorac Cardiovasc Surg 2005;130(1):20-8.

Indexed‎: PubMed 15999036

DOI‎: 10.1016/j.jtcvs.2004.12.006

https://www.ncbi.nlm.nih.gov/pubmed/15999036 (opens new window)

Bleeding after cardiac surgery is associated with an increase in the total cost of the hospital stay. (opens new window)

Newcomb AE, Dignan R, McElduff P, Pearse EJ, Bannon P.

Source‎: Ann Thorac Surg 2020;109(4):1069-78.

Indexed‎: PubMed 31904370

DOI‎: 10.1016/j.athoracsur.2019.11.019

https://www.ncbi.nlm.nih.gov/pubmed/31904370 (opens new window)

Protocol guided bleeding management improves cardiac surgery patient outcomes. (opens new window)

Pearse BL, Smith I, Faulke D, Wall D, Fraser JF, Ryan EG, Drake L, Rapchuk IL, Tesar P, Ziegenfuss M, Fung YL.

Source‎: Vox Sang 2015;109(3):267-79.

Indexed‎: PubMed 25930098

DOI‎: 10.1111/vox.12279

https://www.ncbi.nlm.nih.gov/pubmed/25930098 (opens new window)

Association between bleeding, blood transfusion, and costs among patients with non-ST-segment elevation acute coronary syndromes. (opens new window)

Rao SV, Kaul PR, Liao L, Armstrong PW, Ohman EM, Granger CB, Califf RM, Harrington RA, Eisenstein EL, Mark DB.

Source‎: Am Heart J 2008;155(2):369-74.

Indexed‎: PubMed 18215610

DOI‎: 10.1016/j.ahj.2007.10.014

https://www.ncbi.nlm.nih.gov/pubmed/18215610 (opens new window)

Mortality, length of stay, and cost implications of procedural bleeding after percutaneous interventions using large-bore catheters. (opens new window)

Redfors B, Watson BM, McAndrew T, Palisaitis E, Francese DP, Razavi M, Safirstein J, Mehran R, Kirtane AJ, Généreux P.

Source‎: JAMA Cardiol 2017;2(7):798-802.

Indexed‎: PubMed 28315573

DOI‎: 10.1001/jamacardio.2017.0265

https://www.ncbi.nlm.nih.gov/pubmed/28315573 (opens new window)

Hospital economic impact from hemostatic matrix usage in cardiac surgery. (opens new window)

Tackett SM, Sugarman R, Kreuwel HT, Alvarez P, Nasso G.

Source‎: J Med Econ 2014;17(9):670-6.

Indexed‎: PubMed 24927164

DOI‎: 10.3111/13696998.2014.928638

https://www.ncbi.nlm.nih.gov/pubmed/24927164 (opens new window)

A structured blood conservation programme reduces transfusions and costs in cardiac surgery. (opens new window)

Ternström L, Hyllner M, Backlund E, Schersten H, Jeppsson A.

Source‎: Interact Cardiovasc Thorac Surg 2014;19(5):788-94.

Indexed‎: PubMed 25125140

DOI‎: 10.1093/icvts/ivu266

https://www.ncbi.nlm.nih.gov/pubmed/25125140 (opens new window)

Administration of recombinant activated factor VII in the intensive care unit after complex cardiovascular surgery: clinical and economic outcomes. (opens new window)

Uber WE, Toole JM, Stroud MR, Haney JS, Lazarchick J, Crawford FA Jr, Ikonomidis JS.

Source‎: J Thorac Cardiovasc Surg 2011;141(6):1469-77.e2.

Indexed‎: PubMed 21457998

DOI‎: 10.1016/j.jtcvs.2011.02.033

https://www.ncbi.nlm.nih.gov/pubmed/21457998 (opens new window)

Safety, efficacy, and cost-effectiveness of intraoperative blood salvage in OPCABG with different amount of bleeding: a single-center, retrospective study. (opens new window)

Wang H, Zheng W, Fang W, Meng G, Zhang L, Zhou Y, Gu E, Liu X.

Source‎: J Cardiothorac Surg 2018;13(1):109.

Indexed‎: PubMed 30333028

DOI‎: 10.1186/s13019-018-0794-6

https://www.ncbi.nlm.nih.gov/pubmed/30333028 (opens new window)

Management of blood transfusion in aortic valve surgery: impact of a blood conservation strategy. (opens new window)

Yaffee DW, Smith DE 3rd, Ursomanno PA, Hill FT, Galloway AC, Deanda A, Grossi EA.

Source‎: Ann Thorac Surg 2014;97(1):95-101.

Indexed‎: PubMed 24263014

DOI‎: 10.1016/j.athoracsur.2013.09.057

https://www.ncbi.nlm.nih.gov/pubmed/24263014 (opens new window)

Cost of bleeding in trauma and complex cardiac surgery. (opens new window)

Zbrozek A, Magee G.

Source‎: Clin Ther 2015;37(9):1966-74.

Indexed‎: PubMed 26210074

DOI‎: 10.1016/j.clinthera.2015.06.007

https://www.ncbi.nlm.nih.gov/pubmed/26210074 (opens new window)