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Orthopedic Surgery

Management and Optimization of Hemostasis

Antifibrinolytic Agents

Intraoperative pharmacotherapeutic blood management strategies in total knee arthroplasty. (opens new window)

Banerjee S, Issa K, Pivec R, McElroy MJ, Khanuja HS, Harwin SF, Mont MA.

Source‎: J Knee Surg 2013;26(6):379-85.

Indexed‎: PubMed 23955184

DOI‎: 10.1055/s-0033-1353992

https://www.ncbi.nlm.nih.gov/pubmed/23955184 (opens new window)

Tranexamic acid in patients undergoing noncardiac surgery. (opens new window)

Devereaux PJ, Marcucci M, Painter TW, Conen D, Lomivorotov V, Sessler DI, Chan MTV, Borges FK, Martínez-Zapata MJ, Wang CY, Xavier D, Ofori SN, Wang MK, Efremov S, Landoni G, Kleinlugtenbelt YV, Szczeklik W, Schmartz D, Garg AX, Short TG, Wittmann M, Meyhoff CS, Amir M, Torres D, Patel A, Duceppe E, Ruetzler K, Parlow JL, Tandon V, Fleischmann E, Polanczyk CA, Lamy A, Astrakov SV, Rao M, Wu WKK, Bhatt K, de Nadal M, Likhvantsev VV, Paniagua P, Aguado HJ, Whitlock RP, McGillion MH, Prystajecky M, Vincent J, Eikelboom J, Copland I, Balasubramanian K, Turan A, Bangdiwala SI, Stillo D, Gross PL, Cafaro T, Alfonsi P, Roshanov PS, Belley-Côté EP, Spence J, Richards T, VanHelder T, McIntyre W, Guyatt G, Yusuf S, Leslie K; POISE-3 Investigators

Source‎: N Engl J Med. 2022;386(21):1986-97.

Indexed‎: PubMed 35363452

DOI‎: 10.1056/NEJMoa2201171

https://pubmed.ncbi.nlm.nih.gov/35363452/ (opens new window)

Repeat-dose intravenous tranexamic acid further decreases blood loss in total knee arthroplasty. (opens new window)

Iwai T, Tsuji S, Tomita T, Sugamoto K, Hideki Y, Hamada M.

Source‎: Int Orthop 2013;37(3):441-5.

Indexed‎: PubMed 23371424

DOI‎: 10.1007/s00264-013-1787-7

https://www.ncbi.nlm.nih.gov/pubmed/23371424 (opens new window)

The efficacy of combined use of intraarticular and intravenous tranexamic acid on reducing blood loss and transfusion rate in total knee arthroplasty. (opens new window)

Lin SY, Chen CH, Fu YC, Huang PJ, Chang JK, Huang HT.

Source‎: J Arthroplasty 2015;30(5):776-80.

Indexed‎: PubMed 25534864

DOI‎: 10.1016/j.arth.2014.12.001

https://www.ncbi.nlm.nih.gov/pubmed/25534864 (opens new window)

Oral is as effective as intravenous tranexamic acid at reducing blood loss in thoracolumbar spinal fusions: a prospective randomized trial. (opens new window)

Yu CC, Fidai M, Washington T, Bartol S, Graziano G

Source‎: Spine 2022;47(2):91-8.

Indexed‎: PubMed 34224510

DOI‎: 10.1097/BRS.0000000000004157

https://pubmed.ncbi.nlm.nih.gov/34224510/ (opens new window)

Recombinant Activated Factor VII (rFVIIa)

The use of recombinant factor VIIa for severe intractable bleeding during spine surgery. (opens new window)

Kaw LL Jr, Coimbra R, Potenza BM, Garfin SR, Hoyt DB.

Source‎: Spine 2004;29(12):1384-7.

Indexed‎: PubMed 15187645

https://www.ncbi.nlm.nih.gov/pubmed/15187645 (opens new window)

Topical Hemostatic Agents

A comprehensive review of topical hemostatic agents: efficacy and recommendations for use. (opens new window)

Achneck HE, Sileshi B, Jamiolkowski RM, Albala DM, Shapiro ML, Lawson JH.

Source‎: Ann Surg 2010;251(2):217-28.

Indexed‎: PubMed 20010084

DOI‎: 10.1097/SLA.0b013e3181c3bcca

https://www.ncbi.nlm.nih.gov/pubmed/20010084 (opens new window)

Hemostatic techniques reduce hospital stay following multilevel posterior cervical spine surgery. (opens new window)

Cho SK, Yi JS, Park MS, Hu G, Zebala LP, Pahys JM, Kang MM, Lee DH, Riew KD.

Source‎: J Bone Joint Surg Am 2012;94(21):1952-8.

Indexed‎: PubMed 23138237

DOI‎: 10.2106/JBJS.K.00632

https://www.ncbi.nlm.nih.gov/pubmed/23138237 (opens new window)

The efficacy of bone wax in reduction of perioperative blood loss in total hip arthroplasty via direct anterior approach: a prospective randomized clinical trial. (opens new window)

Mortazavi SMJ, Razzaghof M, Ghadimi E, Seyedtabaei SMM, Vahedian Ardakani M, Moharrami A

Source‎: J Bone Joint Surg Am. 2022;104(20):1805-13.

Indexed‎: PubMed 35984033

DOI‎: 10.2106/JBJS.22.00376

https://pubmed.ncbi.nlm.nih.gov/35984033/ (opens new window)

Use of a fibrin sealant within a blood-saving protocol in patients undergoing revision hip arthroplasty: effects on post-operative blood transfusion and healthcare-related cost analysis. (opens new window)

Scardino M, Martorelli F, D'Amato T, Fenocchio G, Simili V, Grappiolo G, Di Matteo B, Kon E, Lagioia M

Source‎: Int Orthop 2019;43(12):2707-14.

Indexed‎: PubMed 30671601

DOI‎: 10.1007/s00264-019-04291-4

https://www.ncbi.nlm.nih.gov/pubmed/30671601 (opens new window)