Perioperative Care
Management and Optimization of Hemostasis
Antifibrinolytic Agents
Alternatives to allogeneic platelet transfusion. (opens new window)
Source: Br J Haematol 2016;175(3):381-92.
Indexed: PubMed 27650431
DOI: 10.1111/bjh.14338
https://www.ncbi.nlm.nih.gov/pubmed/27650431 (opens new window)
Tranexamic acid in patients undergoing noncardiac surgery. (opens new window)
Source: N Engl J Med. 2022;386(21):1986-97.
Indexed: PubMed 35363452
DOI: 10.1056/NEJMoa2201171
https://pubmed.ncbi.nlm.nih.gov/35363452/ (opens new window)
Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion. (opens new window)
Source: Cochrane Database Syst Rev 2011;(3):CD001886.
Indexed: PubMed 21412876
DOI: 10.1002/14651858.CD001886.pub4
https://www.ncbi.nlm.nih.gov/pubmed/21412876 (opens new window)
Putting the record straight on aprotinin as safe and effective: results from a mixed treatment meta-analysis of trials of aprotinin. (opens new window)
Source: J Thorac Cardiovasc Surg 2013;145(1):234-40.
Indexed: PubMed 22889481
DOI: 10.1016/j.jtcvs.2012.07.018
https://www.ncbi.nlm.nih.gov/pubmed/22889481 (opens new window)
Effect of tranexamic acid on surgical bleeding: systematic review and cumulative meta-analysis. (opens new window)
Source: BMJ 2012;344:e3054.
Indexed: PubMed 22611164
https://www.ncbi.nlm.nih.gov/pubmed/22611164 (opens new window)
Systematic review, meta-analysis and meta-regression of the effect of tranexamic acid on surgical blood loss. (opens new window)
Source: Br J Surg 2013;100(10):1271-9.
Indexed: PubMed 23839785
DOI: 10.1002/bjs.9193
https://www.ncbi.nlm.nih.gov/pubmed/23839785 (opens new window)
Association of intravenous tranexamic acid with thromboembolic events and mortality: a systematic review, meta-analysis, and meta-regression. (opens new window)
Source: JAMA Surg 2021;156(6):e210884.
Indexed: PubMed 33851983
DOI: 10.1001/jamasurg.2021.0884
https://www.ncbi.nlm.nih.gov/pubmed/33851983 (opens new window)
Oral is as effective as intravenous tranexamic acid at reducing blood loss in thoracolumbar spinal fusions: a prospective randomized trial. (opens new window)
Source: Spine 2022;47(2):91-8.
Indexed: PubMed 34224510
DOI: 10.1097/BRS.0000000000004157
https://pubmed.ncbi.nlm.nih.gov/34224510/ (opens new window)
Recombinant Activated Factor VII (rFVIIa)
Aortic dissection and hypothermic arrest in a Jehovah's Witness patient: a case for recombinant factor VIIa? (opens new window)
Source: Can J Anaesth 2006;53(4):353-6.
Indexed: PubMed 16575032
DOI: 10.1007/BF03022498
https://www.ncbi.nlm.nih.gov/pubmed/16575032 (opens new window)
The treatment of bleeding is to stop the bleeding! Treatment of trauma-related hemorrhage. (opens new window)
Source: Transfusion 2009;49 Suppl 5:240S-7S.
Indexed: PubMed 19954486
DOI: 10.1111/j.1537-2995.2008.01987.x
https://www.ncbi.nlm.nih.gov/pubmed/19954486 (opens new window)
Comprehensive Canadian review of the off-label use of recombinant activated factor VII in cardiac surgery. (opens new window)
Source: Circulation 2008;118(4):331-8.
Indexed: PubMed 18606914
DOI: 10.1161/CIRCULATIONAHA.108.764308
https://www.ncbi.nlm.nih.gov/pubmed/18606914 (opens new window)
Recombinant factor VIIa as last-resort treatment of desperate haemorrhage. (opens new window)
Source: Acta Anaesthesiol Scand 2012;56(5):636-44.
Indexed: PubMed 22489992
DOI: 10.1111/j.1399-6576.2012.02688.x
https://www.ncbi.nlm.nih.gov/pubmed/22489992 (opens new window)
Coagulation Factor Concentrates
Prophylactic use of factor IX concentrate in a Jehovah's Witness patient. (opens new window)
Source: Ann Thorac Surg 2009;88(5):1666-8.
Indexed: PubMed 19853132
DOI: 10.1016/j.athoracsur.2009.03.095
https://www.ncbi.nlm.nih.gov/pubmed/19853132 (opens new window)
Bloodless orthotopic heart transplantation in a Jehovah's Witness. (opens new window)
Source: A A Case Rep 2015;4(10):140-2.
Indexed: PubMed 25974419
DOI: 10.1213/XAA.0000000000000067
https://www.ncbi.nlm.nih.gov/pubmed/25974419 (opens new window)
Fibrinogen replacement therapy: a critical review of the literature. (opens new window)
Source: Blood Transfus 2012;10(1):23-7.
Indexed: PubMed 22153684
DOI: 10.2450/2011.0015-11
https://www.ncbi.nlm.nih.gov/pubmed/22153684 (opens new window)
First-line therapy with coagulation factor concentrates combined with point-of-care coagulation testing is associated with decreased allogeneic blood transfusion in cardiovascular surgery: a retrospective, single-center cohort study. (opens new window)
Source: Anesthesiology 2011;115(6):1179-91.
Indexed: PubMed 21970887
DOI: 10.1097/ALN.0b013e31823497dd
https://www.ncbi.nlm.nih.gov/pubmed/21970887 (opens new window)
Prophylactic fibrinogen infusion reduces bleeding after coronary artery bypass surgery. A prospective randomised pilot study. (opens new window)
Source: Thromb Haemost 2009;102(1):137-44.
Indexed: PubMed 19572078
DOI: 10.1160/TH08-09-0587
https://www.ncbi.nlm.nih.gov/pubmed/19572078 (opens new window)
Fibrinogen as a therapeutic target for bleeding: a review of critical levels and replacement therapy. (opens new window)
Source: Transfusion 2014;54(5):1389-405.
Indexed: PubMed 24117955
DOI: 10.1111/trf.12431
https://www.ncbi.nlm.nih.gov/pubmed/24117955 (opens new window)
Effects of fibrinogen concentrate as first-line therapy during major aortic replacement surgery: a randomized, placebo-controlled trial. (opens new window)
Source: Anesthesiology 2013;118(1):40-50.
Indexed: PubMed 23249928
DOI: 10.1097/ALN.0b013e3182715d4d
https://www.ncbi.nlm.nih.gov/pubmed/23249928 (opens new window)
Bleeding in a Jehovah's Witness patient undergoing a redo aortic valve replacement controlled with cryoprecipitate and a prothrombin complex concentrate. (opens new window)
Source: Can J Anaesth 2012;59(3):299-303.
Indexed: PubMed 22161243
DOI: 10.1007/s12630-011-9647-7
https://www.ncbi.nlm.nih.gov/pubmed/22161243 (opens new window)
Desmopressin
Effects of desmopressin on platelet function under conditions of hypothermia and acidosis: an in vitro study using multiple electrode aggregometry. (opens new window)
Source: Anaesthesia 2010;65(7):688-91.
Indexed: PubMed 20477783
DOI: 10.1111/j.1365-2044.2010.06367.x
https://www.ncbi.nlm.nih.gov/pubmed/20477783 (opens new window)
Viscoelastic Tests to Identify Surgical or Coagulopathic Bleeding
Management of severe perioperative bleeding: Guidelines from the European Society of Anaesthesiology. (opens new window)
Source: Eur J Anaesthesiol 2013;30(6):270-382.
Indexed: PubMed 23656742
DOI: 10.1097/EJA.0b013e32835f4d5b
https://www.ncbi.nlm.nih.gov/pubmed/23656742 (opens new window)
Use of rotation thromboelastometry (ROTEM) to achieve successful treatment of polytrauma with fibrinogen concentrate and prothrombin complex concentrate. (opens new window)
Source: Anaesthesia 2010;65(2):199-203.
Indexed: PubMed 19995349
https://www.ncbi.nlm.nih.gov/pubmed/19995349 (opens new window)