Trauma and Emergency Medicine
Management and Optimization of Hemostasis
Antifibrinolytic Agents
Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH-3): a randomised, placebo-controlled trial. (opens new window)
Source: Lancet 2019;394(10210):1713-23.
Indexed: PubMed 31623894
DOI: 10.1016/S0140-6736(19)32233-0
https://www.ncbi.nlm.nih.gov/pubmed/31623894 (opens new window)
Alternatives to allogeneic platelet transfusion. (opens new window)
Source: Br J Haematol 2016;175(3):381-92.
Indexed: PubMed 27650431
DOI: 10.1111/bjh.14338
https://www.ncbi.nlm.nih.gov/pubmed/27650431 (opens new window)
Antifibrinolytic drugs for acute traumatic injury. (opens new window)
Source: Cochrane Database Syst Rev 2015;(5):CD004896.
Indexed: PubMed 25956410
DOI: 10.1002/14651858.CD004896.pub4
https://www.ncbi.nlm.nih.gov/pubmed/25956410 (opens new window)
Association of cryoprecipitate and tranexamic acid with improved survival following wartime injury: findings from the MATTERs II Study. (opens new window)
Source: JAMA Surg 2013;148(3):218-25.
Indexed: PubMed 23670117
DOI: 10.1001/jamasurg.2013.764
https://www.ncbi.nlm.nih.gov/pubmed/23670117 (opens new window)
The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial. (opens new window)
Source: Lancet 2011;377(9771):1096-101, 1101.e1-2.
Indexed: PubMed 21439633
DOI: 10.1016/S0140-6736(11)60278-X
https://www.ncbi.nlm.nih.gov/pubmed/21439633 (opens new window)
Topical tranexamic acid compared with anterior nasal packing for treatment of epistaxis in patients taking antiplatelet drugs: randomized controlled trial. (opens new window)
Source: Acad Emerg Med 2018;25(3):261-6.
Indexed: PubMed 29125679
DOI: 10.1111/acem.13345
https://www.ncbi.nlm.nih.gov/pubmed/29125679 (opens new window)
Recombinant Activated Factor VII (rFVIIa)
Efficacy of recombinant activated Factor VII in patients with massive uncontrolled bleeding: a retrospective observational analysis. (opens new window)
Source: Transfusion 2009;49(3):570-7.
Indexed: PubMed 19040498
DOI: 10.1111/j.1537-2995.2008.02001.x
https://www.ncbi.nlm.nih.gov/pubmed/19040498 (opens new window)
The treatment of bleeding is to stop the bleeding! Treatment of trauma-related hemorrhage. (opens new window)
Source: Transfusion 2009;49 Suppl 5:240S-7S.
Indexed: PubMed 19954486
DOI: 10.1111/j.1537-2995.2008.01987.x
https://www.ncbi.nlm.nih.gov/pubmed/19954486 (opens new window)
Coagulation Factor Concentrates
The exclusive use of coagulation factor concentrates enables reversal of coagulopathy and decreases transfusion rates in patients with major blunt trauma. (opens new window)
Source: Injury 2013;44(2):209-16.
Indexed: PubMed 23000050
DOI: 10.1016/j.injury.2012.08.047
https://www.ncbi.nlm.nih.gov/pubmed/23000050 (opens new window)
Desmopressin
Desmopressin is a transfusion sparing option to reverse platelet dysfunction in patients with severe traumatic brain injury. (opens new window)
Source: J Trauma Acute Care Surg 2020;88(1):80-6.
Indexed: PubMed 31688782
DOI: 10.1097/TA.0000000000002521
https://www.ncbi.nlm.nih.gov/pubmed/31688782 (opens new window)
Viscoelastic Tests to Identify Surgical or Coagulopathic Bleeding
Successful rotational thromboelastometry-guided treatment of traumatic haemorrhage, hyperfibrinolysis and coagulopathy. (opens new window)
Source: Acta Anaesthesiol Scand 2010;54(1):111-7.
Indexed: PubMed 19860752
DOI: 10.1111/j.1399-6576.2009.02132.x
https://www.ncbi.nlm.nih.gov/pubmed/19860752 (opens new window)
Use of rotation thromboelastometry (ROTEM) to achieve successful treatment of polytrauma with fibrinogen concentrate and prothrombin complex concentrate. (opens new window)
Source: Anaesthesia 2010;65(2):199-203.
Indexed: PubMed 19995349
https://www.ncbi.nlm.nih.gov/pubmed/19995349 (opens new window)