Beta Thalassemia Major (Pediatrics)
Pharmacological Induction of Fetal Hemoglobin Synthesis
Hydroxyurea (Hydroxycarbamide) Therapy
Efficacy of hydroxyurea in providing transfusion independence in β-thalassemia. (opens new window)
Source: J Pediatr Hematol Oncol 2011;33(5):339-43.
Indexed: PubMed 21602718
DOI: 10.1097/MPH.0b013e31821b0770
https://www.ncbi.nlm.nih.gov/pubmed/21602718 (opens new window)
Gγ-Xmn I polymorphism: a significant determinant of β-thalassemia treatment without blood transfusion. (opens new window)
Source: J Pediatr Hematol Oncol 2013;35(4):e153-6.
Indexed: PubMed 23389500
DOI: 10.1097/MPH.0b013e31827e8662
https://www.ncbi.nlm.nih.gov/pubmed/23389500 (opens new window)
Efficacy of hydroxyurea (HU) in reduction of pack red cell (PRC) transfusion requirement among children having beta-thalassemia major: Karachi HU trial (KHUT). (opens new window)
Source: J Pediatr Hematol Oncol 2007;29(11):743-6.
Indexed: PubMed 17984691
DOI: 10.1097/MPH.0b013e318157fd75
https://www.ncbi.nlm.nih.gov/pubmed/17984691 (opens new window)
Hydroxyurea can eliminate transfusion requirements in children with severe beta-thalassemia. (opens new window)
Source: Blood 2003;102(4):1529-30.
Indexed: PubMed 12702505
DOI: 10.1182/blood-2003-01-0117
https://www.ncbi.nlm.nih.gov/pubmed/12702505 (opens new window)
Decreased transfusion needs associated with hydroxyurea therapy in Algerian patients with thalassemia major or intermedia. (opens new window)
Source: Transfusion 2007;47(10):1830-6.
Indexed: PubMed 17880608
DOI: 10.1111/j.1537-2995.2007.01399.x
https://www.ncbi.nlm.nih.gov/pubmed/17880608 (opens new window)
Hydroxyurea can reduce or eliminate transfusion requirements in children with major and intermediate thalassemia. (opens new window)
Source: Iran J Blood Cancer 2009;1(4):147-50.
Indexed: IMEMR 107228
https://www.ijbc.ir/browse.php?a_id=4&sid=1&slc_lang=en (opens new window)
Genotype-phenotype relationship of patients with β-thalassemia taking hydroxyurea: a 13-year experience in Iran. (opens new window)
Source: Int J Hematol 2012;95(1):51-6.
Indexed: PubMed 22180324
DOI: 10.1007/s12185-011-0985-6
https://www.ncbi.nlm.nih.gov/pubmed/22180324 (opens new window)
Fetal globin stimulant therapies in the beta-hemoglobinopathies: principles and current potential. (opens new window)
Source: Pediatr Ann 2008;37(5):339-46.
Indexed: PubMed 18543545
https://www.ncbi.nlm.nih.gov/pubmed/18543545 (opens new window)
A randomised double-blind placebo-controlled clinical trial of oral hydroxyurea for transfusion-dependent β-thalassaemia. (opens new window)
Source: Sci Rep. 2022;12(1):2752.
Indexed: PubMed 35177777
DOI: 10.1038/s41598-022-06774-8
https://pubmed.ncbi.nlm.nih.gov/35177777/ (opens new window)
Response to hydroxyurea treatment in Iranian transfusion-dependent beta-thalassemia patients. (opens new window)
Source: Haematologica 2004;89(10):1172-8.
Indexed: PubMed 15477200
https://www.ncbi.nlm.nih.gov/pubmed/15477200 (opens new window)
Hydroxyurea therapy in 49 patients with major beta-thalassemia. (opens new window)
Source: Arch Iran Med 2009;12(3):295-7.
Indexed: PubMed 19400608
https://www.ncbi.nlm.nih.gov/pubmed/19400608 (opens new window)
Recombinant Erythropoietin (Alone or in Combination With Other Agents)
Use of hydroxyurea and recombinant erythropoietin in management of homozygous ß⁰ thalassemia. (opens new window)
Source: J Pediatr Hematol Oncol 2002;24(9):777-8.
Indexed: PubMed 12468925
https://www.ncbi.nlm.nih.gov/pubmed/12468925 (opens new window)
Termination of transfusion dependence in beta-thalassemia: two-year experience with recombinant human erythropoietin. (opens new window)
Source: Pediatr Hematol Oncol 1997;14(3):285-7.
Indexed: PubMed 9185215
https://www.ncbi.nlm.nih.gov/pubmed/9185215 (opens new window)
Other Agents
Fetal globin gene inducers: novel agents and new potential. (opens new window)
Source: Ann N Y Acad Sci 2010;1202:158-64.
Indexed: PubMed 20712788
DOI: 10.1111/j.1749-6632.2010.05593.x
https://www.ncbi.nlm.nih.gov/pubmed/20712788 (opens new window)