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外傷・救急医療

止血の管理と最適化

抗線溶薬

Alternatives to allogeneic platelet transfusion. (新しいタブで開く)

Desborough MJ, Smethurst PA, Estcourt LJ, Stanworth SJ.

出典‎: Br J Haematol 2016;175(3):381-92.

インデックス‎: PubMed 27650431

DOI‎: 10.1111/bjh.14338

https://www.ncbi.nlm.nih.gov/pubmed/27650431 (新しいタブで開く)

Antifibrinolytic drugs for acute traumatic injury. (新しいタブで開く)

Ker K, Roberts I, Shakur H, Coats TJ.

出典‎: Cochrane Database Syst Rev 2015;(5):CD004896.

インデックス‎: PubMed 25956410

DOI‎: 10.1002/14651858.CD004896.pub4

https://www.ncbi.nlm.nih.gov/pubmed/25956410 (新しいタブで開く)

Association of cryoprecipitate and tranexamic acid with improved survival following wartime injury: findings from the MATTERs II Study. (新しいタブで開く)

Morrison JJ, Ross JD, Dubose JJ, Jansen JO, Midwinter MJ, Rasmussen TE.

出典‎: JAMA Surg 2013;148(3):218-25.

インデックス‎: PubMed 23670117

DOI‎: 10.1001/jamasurg.2013.764

https://www.ncbi.nlm.nih.gov/pubmed/23670117 (新しいタブで開く)

The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial. (新しいタブで開く)

Roberts I, Shakur H, Afolabi A, Brohi K, Coats T, Dewan Y, Gando S, Guyatt G, Hunt BJ, Morales C, Perel P, Prieto-Merino D, Woolley T; CRASH-2 collaborators.

出典‎: Lancet 2011;377(9771):1096-101, 1101.e1-2.

インデックス‎: PubMed 21439633

DOI‎: 10.1016/S0140-6736(11)60278-X

https://www.ncbi.nlm.nih.gov/pubmed/21439633 (新しいタブで開く)

遺伝子組換え活性型血液凝固第Ⅶ因子製剤(rFVIIa)

The treatment of bleeding is to stop the bleeding! Treatment of trauma-related hemorrhage. (新しいタブで開く)

Boffard KD, Choong PI, Kluger Y, Riou B, Rizoli SB, Rossaint R, Warren B; NovoSeven Trauma Study Group.

出典‎: Transfusion 2009;49 Suppl 5:240S-7S.

インデックス‎: PubMed 19954486

DOI‎: 10.1111/j.1537-2995.2008.01987.x

https://www.ncbi.nlm.nih.gov/pubmed/19954486 (新しいタブで開く)

濃縮凝固因子製剤

The exclusive use of coagulation factor concentrates enables reversal of coagulopathy and decreases transfusion rates in patients with major blunt trauma. (新しいタブで開く)

Innerhofer P, Westermann I, Tauber H, Breitkopf R, Fries D, Kastenberger T, El Attal R, Strasak A, Mittermayr M.

出典‎: Injury 2013;44(2):209-16.

インデックス‎: PubMed 23000050

DOI‎: 10.1016/j.injury.2012.08.047

https://www.ncbi.nlm.nih.gov/pubmed/23000050 (新しいタブで開く)

デスモプレシン

Desmopressin is a transfusion sparing option to reverse platelet dysfunction in patients with severe traumatic brain injury. (新しいタブで開く)

Furay EJ, Daley MJ, Satarasinghe P, Lara S, Aydelotte JD, Teixeira PG, Coopwood TB, Ali S, Brown CVR

出典‎: J Trauma Acute Care Surg 2020;88(1):80-6.

インデックス‎: PubMed 31688782

DOI‎: 10.1097/TA.0000000000002521

https://www.ncbi.nlm.nih.gov/pubmed/31688782 (新しいタブで開く)

外科的出血か凝固異常による出血かを同定するための血液粘弾性試験

Successful rotational thromboelastometry-guided treatment of traumatic haemorrhage, hyperfibrinolysis and coagulopathy. (新しいタブで開く)

Brenni M, Worn M, Brüesch M, Spahn DR, Ganter MT.

出典‎: Acta Anaesthesiol Scand 2010;54(1):111-7.

インデックス‎: PubMed 19860752

DOI‎: 10.1111/j.1399-6576.2009.02132.x

https://www.ncbi.nlm.nih.gov/pubmed/19860752 (新しいタブで開く)