Resultados clínicos

Carson JL, Terrin ML, Noveck H, Sanders DW, Chaitman BR, Rhoads GG, Nemo G, Dragert K, Beaupre L, Hildebrand K, Macaulay W, Lewis C, Cook DR, Dobbin G, Zakriya KJ, Apple FS, Horney RA, Magaziner J; FOCUS Investigators.

Fonte‎: N Engl J Med 2011;365(26):2453-62.

Indexado‎: PubMed 22168590

DOI‎: 10.1056/NEJMoa1012452

https://www.ncbi.nlm.nih.gov/pubmed/22168590 (abre nova janela)

Association between bleeding events and in-hospital mortality after percutaneous coronary intervention. (abre nova janela)

Chhatriwalla AK, Amin AP, Kennedy KF, House JA, Cohen DJ, Rao SV, Messenger JC, Marso SP; National Cardiovascular Data Registry.

Fonte‎: JAMA 2013;309(10):1022-9.

Indexado‎: PubMed 23483177

DOI‎: 10.1001/jama.2013.1556

https://www.ncbi.nlm.nih.gov/pubmed/23483177 (abre nova janela)

How good patient blood management leads to excellent outcomes in Jehovah's Witness patients undergoing cardiac surgery. (abre nova janela)

Emmert MY, Salzberg SP, Theusinger OM, Felix C, Plass A, Hoerstrup SP, Falk V, Gruenenfelder J.

Fonte‎: Interact Cardiovasc Thorac Surg 2011;12(2):183-8.

Indexado‎: PubMed 20829389

DOI‎: 10.1510/icvts.2010.242552

https://www.ncbi.nlm.nih.gov/pubmed/20829389 (abre nova janela)

Effect of blood transfusion on long-term survival after cardiac operation. (abre nova janela)

Engoren MC, Habib RH, Zacharias A, Schwann TA, Riordan CJ, Durham SJ.

Fonte‎: Ann Thorac Surg 2002;74(4):1180-6.

Indexado‎: PubMed 12400765

https://www.ncbi.nlm.nih.gov/pubmed/12400765 (abre nova janela)

Decreased erythrocyte deformability after transfusion and the effects of erythrocyte storage duration. (abre nova janela)

Frank SM, Abazyan B, Ono M, Hogue CW, Cohen DB, Berkowitz DE, Ness PM, Barodka VM.

Fonte‎: Anesth Analg 2013;116(5):975-81.

Indexado‎: PubMed 23449853

DOI‎: 10.1213/ANE.0b013e31828843e6

https://www.ncbi.nlm.nih.gov/pubmed/23449853 (abre nova janela)

Risk-adjusted clinical outcomes in patients enrolled in a bloodless program. (abre nova janela)

Frank SM, Wick EC, Dezern AE, Ness PM, Wasey JO, Pippa AC, Dackiw E, Resar LM.

Fonte‎: Transfusion 2014;54(10 Pt 2):2668-77.

Indexado‎: PubMed 24942198

DOI‎: 10.1111/trf.12752

https://www.ncbi.nlm.nih.gov/pubmed/24942198 (abre nova janela)

Blood transfusion in cardiac surgery is a risk factor for increased hospital length of stay in adult patients. (abre nova janela)

Galas FR, Almeida JP, Fukushima JT, Osawa EA, Nakamura RE, Silva CM, de Almeida EP, Auler JO, Vincent JL, Hajjar LA.

Fonte‎: J Cardiothorac Surg 2013;8:54.

Indexado‎: PubMed 23531208

DOI‎: 10.1186/1749-8090-8-54

https://www.ncbi.nlm.nih.gov/pubmed/23531208 (abre nova janela)

Optimizing safety and success: the advantages of bloodless cardiac surgery. A systematic review and meta-analysis of outcomes in Jehovah's Witnesses. (abre nova janela)

Gemelli M, Italiano EG, Geatti V, Addonizio M, Cao I, Dimagli A, Dokollari A, Tarzia V, Gallo M, Ferrari E, Slaughter MS, Gerosa G

Fonte‎: Curr Probl Cardiol. 2024 ;49(1 Pt B):102078.

Indexado‎: PubMed 37716536

DOI‎: 10.1016/j.cpcardiol.2023.102078

https://pubmed.ncbi.nlm.nih.gov/37716536/ (abre nova janela)

Restrictive blood transfusion practices are associated with improved patient outcomes. (abre nova janela)

Goodnough LT, Maggio P, Hadhazy E, Shieh L, Hernandez-Boussard T, Khari P, Shah N.

Fonte‎: Transfusion 2014;54(10 Pt 2):2753-9.

Indexado‎: PubMed 24995770

DOI‎: 10.1111/trf.12723

https://www.ncbi.nlm.nih.gov/pubmed/24995770 (abre nova janela)

Patient blood management in cardiac surgery results in fewer transfusions and better outcome. (abre nova janela)

Gross I, Seifert B, Hofmann A, Spahn DR.

Fonte‎: Transfusion 2015;55(5):1075-81.

Indexado‎: PubMed 25565302

DOI‎: 10.1111/trf.12946

https://www.ncbi.nlm.nih.gov/pubmed/25565302 (abre nova janela)

Costs and outcomes after cardiac surgery in patients refusing transfusion compared with those who do not: a case-matched study. (abre nova janela)

Guinn NR, Roberson RS, White W, Cowper PA, Broomer B, Milano C, Chiricolo A, Hill S.

Fonte‎: Transfusion 2015;55(12):2791-8.

Indexado‎: PubMed 26183817

DOI‎: 10.1111/trf.13246

https://www.ncbi.nlm.nih.gov/pubmed/26183817 (abre nova janela)

Blood transfusion and 30-day mortality in patients with coronary artery disease and anemia following noncardiac surgery. (abre nova janela)

Hollis RH, Singletary BA, McMurtrie JT, Graham LA, Richman JS, Holcomb CN, Itani KM, Maddox TM, Hawn MT.

Fonte‎: JAMA Surg 2016;151(2):139-45.

Indexado‎: PubMed 26444569

DOI‎: 10.1001/jamasurg.2015.3420

https://www.ncbi.nlm.nih.gov/pubmed/26444569 (abre nova janela)

Blood transfusion and infection after cardiac surgery. (abre nova janela)

Horvath KA, Acker MA, Chang H, Bagiella E, Smith PK, Iribarne A, Kron IL, Lackner P, Argenziano M, Ascheim DD, Gelijns AC, Michler RE, Van Patten D, Puskas JD, O'Sullivan K, Kliniewski D, Jeffries NO, O'Gara PT, Moskowitz AJ, Blackstone EH.

Fonte‎: Ann Thorac Surg 2013;95(6):2194-201.

Indexado‎: PubMed 23647857

DOI‎: 10.1016/j.athoracsur.2012.11.078

https://www.ncbi.nlm.nih.gov/pubmed/23647857 (abre nova janela)

Incidence and impact of a single-unit red blood cell transfusion: analysis of The Society of Thoracic Surgeons Database 2010-2019. (abre nova janela)

Ivascu Girardi N, Cushing MM, Evered LA, Benedetto U, Schwann TA, Kurlansky P, Habib RH, Gaudino MFL

Fonte‎: Ann Thorac Surg. 2023;115(4):1035-41. Epub 2022 Dec 15.

Indexado‎: PubMed 36528125

DOI‎: 10.1016/j.athoracsur.2022.11.037

https://pubmed.ncbi.nlm.nih.gov/36528125/ (abre nova janela)

Transfusion of blood during cardiac surgery is associated with higher long-term mortality in low-risk patients. (abre nova janela)

Jakobsen CJ, Ryhammer PK, Tang M, Andreasen JJ, Mortensen PE.

Fonte‎: Eur J Cardiothorac Surg 2012;42(1):114-20.

Indexado‎: PubMed 22241009

DOI‎: 10.1093/ejcts/ezr242

https://www.ncbi.nlm.nih.gov/pubmed/22241009 (abre nova janela)

Cardiac surgery in Jehovah's Witness patients: ten-year experience. (abre nova janela)

Jassar AS, Ford PA, Haber HL, Isidro A, Swain JD, Bavaria JE, Bridges CR.

Fonte‎: Ann Thorac Surg 2012;93(1):19-25.

Indexado‎: PubMed 21978873

DOI‎: 10.1016/j.athoracsur.2011.06.029

https://www.ncbi.nlm.nih.gov/pubmed/21978873 (abre nova janela)

Results of open heart surgery in Jehovah's Witnesses patients. (abre nova janela)

Juraszek A, Dziodzio T, Roedler S, Kral A, Hutschala D, Wolner E, Grimm M, Czerny M.

Fonte‎: J Cardiovasc Surg (Torino) 2009;50(2):247-50.

Indexado‎: PubMed 19329922

https://www.ncbi.nlm.nih.gov/pubmed/19329922 (abre nova janela)

Perioperative red blood cell transfusion is associated with adverse cardiovascular outcomes in heart valve surgery. (abre nova janela)

Kim HJ, Kim JE, Lee JY, Lee SH, Jung JS, Son HS

Fonte‎: Anesth Analg. 2023 1;137(1):153-61. Epub 2022 Nov 1.

Indexado‎: PubMed 36730895

DOI‎: 10.1213/ANE.0000000000006245

https://pubmed.ncbi.nlm.nih.gov/36730895/ (abre nova janela)

Blood product conservation is associated with improved outcomes and reduced costs after cardiac surgery. (abre nova janela)

LaPar DJ, Crosby IK, Ailawadi G, Ad N, Choi E, Spiess BD, Rich JB, Kasirajan V, Fonner E Jr, Kron IL, Speir AM; Investigators for the Virginia Cardiac Surgery Quality Initiative.

Fonte‎: J Thorac Cardiovasc Surg 2013;145(3):796-804.

Indexado‎: PubMed 23414992

DOI‎: 10.1016/j.jtcvs.2012.12.041

https://www.ncbi.nlm.nih.gov/pubmed/23414992 (abre nova janela)

Transfusion of blood components and postoperative infection in patients undergoing cardiac surgery. (abre nova janela)

Leal-Noval SR, Rincón-Ferrari MD, García-Curiel A, Herruzo-Avilés A, Camacho-Laraña P, Garnacho-Montero J, Amaya-Villar R.

Fonte‎: Chest 2001;119(5):1461-8.

Indexado‎: PubMed 11348954

https://www.ncbi.nlm.nih.gov/pubmed/11348954 (abre nova janela)

Red blood cell transfusions impact pneumonia rates after coronary artery bypass grafting. (abre nova janela)

Likosky DS, Paone G, Zhang M, Rogers MA, Harrington SD, Theurer PF, DeLucia A 3rd, Fishstrom A, Camaj A, Prager RL; Michigan Society of Thoracic and Cardiovascular Surgeons Quality Collaborative.

Fonte‎: Ann Thorac Surg 2015;100(3):794-800.

Indexado‎: PubMed 26209489

DOI‎: 10.1016/j.athoracsur.2015.03.089

https://www.ncbi.nlm.nih.gov/pubmed/26209489 (abre nova janela)

The effect of universal leukoreduction on postoperative infections and length of hospital stay in elective orthopedic and cardiac surgery. (abre nova janela)

Llewelyn CA, Taylor RS, Todd AA, Stevens W, Murphy MF, Williamson LM; Leucodepletion Study Group.

Fonte‎: Transfusion 2004;44(4):489-500.

Indexado‎: PubMed 15043563

DOI‎: 10.1111/j.1537-2995.2004.03325.x

https://www.ncbi.nlm.nih.gov/pubmed/15043563 (abre nova janela)

Efficacy of red blood cell transfusion in the critically ill: a systematic review of the literature. (abre nova janela)

Marik PE, Corwin HL.

Fonte‎: Crit Care Med 2008;36(9):2667-74.

Indexado‎: PubMed 18679112

DOI‎: 10.1097/CCM.0b013e3181844677

https://www.ncbi.nlm.nih.gov/pubmed/18679112 (abre nova janela)

Outcomes from cardiac surgery in Jehovah's Witness patients: experience over twenty-one years. (abre nova janela)

Marinakis S, Van der Linden P, Tortora R, Massaut J, Pierrakos C, Wauthy P.

Fonte‎: J Cardiothorac Surg 2016;11(1):67.

Indexado‎: PubMed 27079663

DOI‎: 10.1186/s13019-016-0455-6

https://www.ncbi.nlm.nih.gov/pubmed/27079663 (abre nova janela)

Short term outcomes after cardiac surgery in a Jehovah's Witness population: an institutional experience. (abre nova janela)

Marshall L, Krampl C, Vrtik M, Haluska B, Griffin R, Mundy J, Shah P.

Fonte‎: Heart Lung Circ 2012;21(2):101-4.

Indexado‎: PubMed 22047753

DOI‎: 10.1016/j.hlc.2011.10.003

https://www.ncbi.nlm.nih.gov/pubmed/22047753 (abre nova janela)

Strategies and outcomes of cardiac surgery in Jehovah's Witnesses. (abre nova janela)

Moraca RJ, Wanamaker KM, Bailey SH, McGregor WE, Benckart DH, Maher TD, Magovern GJ Jr.

Fonte‎: J Card Surg 2011;26(2):135-43.

Indexado‎: PubMed 21348894

DOI‎: 10.1111/j.1540-8191.2011.01215.x

https://www.ncbi.nlm.nih.gov/pubmed/21348894 (abre nova janela)

The impact of blood conservation on outcomes in cardiac surgery: is it safe and effective? (abre nova janela)

Moskowitz DM, McCullough JN, Shander A, Klein JJ, Bodian CA, Goldweit RS, Ergin MA.

Fonte‎: Ann Thorac Surg 2010;90(2):451-8.

Indexado‎: PubMed 20667328

DOI‎: 10.1016/j.athoracsur.2010.04.089

https://www.ncbi.nlm.nih.gov/pubmed/20667328 (abre nova janela)

Forum for debate: safety of allogeneic blood transfusion alternatives in the surgical/critically ill patient. [Foro de debate: seguridad de las alternativas a la transfusión alogénica en el paciente quirúrgico y/o crítico.] [English, Spanish] (abre nova janela)

Muñoz Gómez M, Bisbe Vives E, Basora Macaya M, García Erce JA, Gómez Luque A, Leal-Noval SR, Colomina MJ, Comin Colet J, Contreras Barbeta E, Cuenca Espiérrez J, Garcia de Lorenzo Y Mateos A, Gomollón García F, Izuel Ramí M, Moral García MV, Montoro Ronsano JB, Páramo Fernández JA, Pereira Saavedra A, Quintana Diaz M, Remacha Sevilla Á, Salinas Argente R, Sánchez Pérez C, Tirado Anglés G, Torrabadella de Reinoso P.

Fonte‎: Med Intensiva 2015;39(9):552-62.

Indexado‎: PubMed 26183121

DOI‎: 10.1016/j.medin.2015.05.006

https://www.ncbi.nlm.nih.gov/pubmed/26183121 (abre nova janela)

Increased mortality, postoperative morbidity, and cost after red blood cell transfusion in patients having cardiac surgery. (abre nova janela)

Murphy GJ, Reeves BC, Rogers CA, Rizvi SI, Culliford L, Angelini GD.

Fonte‎: Circulation 2007;116(22):2544-52.

Indexado‎: PubMed 17998460

DOI‎: 10.1161/CIRCULATIONAHA.107.698977

https://www.ncbi.nlm.nih.gov/pubmed/17998460 (abre nova janela)

The association of perioperative transfusion with 30-day morbidity and mortality in patients undergoing major vascular surgery. (abre nova janela)

Obi AT, Park YJ, Bove P, Cuff R, Kazmers A, Gurm HS, Grossman PM, Henke PK.

Fonte‎: J Vasc Surg 2015;61(4):1000-9.e1.

Indexado‎: PubMed 25596978

DOI‎: 10.1016/j.jvs.2014.10.106

https://www.ncbi.nlm.nih.gov/pubmed/25596978 (abre nova janela)

Relationships among haemoglobin level, packed red cell transfusion and clinical outcomes in patients after cardiac surgery. (abre nova janela)

Oliver E, Carrio ML, Rodríguez-Castro D, Javierre C, Farrero E, Torrado H, Castells E, Ventura JL.

Fonte‎: Intensive Care Med 2009;35(9):1548-55.

Indexado‎: PubMed 19547956

DOI‎: 10.1007/s00134-009-1526-0

https://www.ncbi.nlm.nih.gov/pubmed/19547956 (abre nova janela)

Transfusion rate as a quality metric: is blood conservation a learnable skill? (abre nova janela)

Paone G, Brewer R, Likosky DS, Theurer PF, Bell GF, Cogan CM, Prager RL; Membership of the Michigan Society of Thoracic and Cardiovascular Surgeons.

Fonte‎: Ann Thorac Surg 2013;96(4):1279-86.

Indexado‎: PubMed 23915586

DOI‎: 10.1016/j.athoracsur.2013.05.045

https://www.ncbi.nlm.nih.gov/pubmed/23915586 (abre nova janela)

Transfusion of 1 and 2 units of red blood cells is associated with increased morbidity and mortality. (abre nova janela)

Paone G, Likosky DS, Brewer R, Theurer PF, Bell GF, Cogan CM, Prager RL; Membership of the Michigan Society of Thoracic and Cardiovascular Surgeons.

Fonte‎: Ann Thorac Surg 2014;97(1):87-94.

Indexado‎: PubMed 24094521

DOI‎: 10.1016/j.athoracsur.2013.07.020

https://www.ncbi.nlm.nih.gov/pubmed/24094521 (abre nova janela)

Bloodless lung transplantation in Jehovah's Witnesses: impact on perioperative parameters and outcome compared with a matched control group. (abre nova janela)

Partovi S, Bruckner BA, Staub D, Ortiz G, Scheinin SA, Seethamraju H, Loebe M.

Fonte‎: Transplant Proc 2013;45(1):335-41.

Indexado‎: PubMed 23267815

DOI‎: 10.1016/j.transproceed.2012.06.057

https://www.ncbi.nlm.nih.gov/pubmed/23267815 (abre nova janela)

Outcome of patients who refuse transfusion after cardiac surgery: a natural experiment with severe blood conservation. (abre nova janela)

Pattakos G, Koch CG, Brizzio ME, Batizy LH, Sabik JF 3rd, Blackstone EH, Lauer MS.

Fonte‎: Arch Intern Med 2012;172(15):1154-60.

Indexado‎: PubMed 22751620

DOI‎: 10.1001/archinternmed.2012.2449

https://www.ncbi.nlm.nih.gov/pubmed/22751620 (abre nova janela)

Mid-term clinical outcomes in cardiac surgery of Jehovah's Witnesses. (abre nova janela)

Pompei E, Tursi V, Guzzi G, Vendramin I, Ius F, Muzzi R, Auci E, Badano LP, Livi U.

Fonte‎: J Cardiovasc Med (Hagerstown) 2010;11(3):170-4.

Indexado‎: PubMed 19934767

DOI‎: 10.2459/JCM.0b013e3283330752

https://www.ncbi.nlm.nih.gov/pubmed/19934767 (abre nova janela)

Impact of a blood conservation program on 30-day morbidity and mortality: a cohort study. (abre nova janela)

Ramanan B, Burns TL, Sugimoto JT, Forse RA.

Fonte‎: J Surg Res 2014;187(1):343-9.

Indexado‎: PubMed 24189177

DOI‎: 10.1016/j.jss.2013.10.005

https://www.ncbi.nlm.nih.gov/pubmed/24189177 (abre nova janela)

Major bleeding, transfusions, and anemia: the deadly triad of cardiac surgery. (abre nova janela)

Ranucci M, Baryshnikova E, Castelvecchio S, Pelissero G; Surgical and Clinical Outcome Research (SCORE) Group.

Fonte‎: Ann Thorac Surg 2013;96(2):478-85.

Indexado‎: PubMed 23673069

DOI‎: 10.1016/j.athoracsur.2013.03.015

https://www.ncbi.nlm.nih.gov/pubmed/23673069 (abre nova janela)

Cirugía cardiaca sin sangre en testigos de Jehová: resultados frente a grupo control. Bloodless cardiac surgery in Jehovah's Witnesses: outcomes compared with a control group. [Spanish, English] (abre nova janela)

Reyes G, Nuche JM, Sarraj A, Cobiella J, Orts M, Martin G, Celemín R, Montalvo E, Martínez-Elbal L, Duarte J.

Fonte‎: Rev Esp Cardiol 2007;60(7):727-31.

Indexado‎: PubMed 17663857

https://www.ncbi.nlm.nih.gov/pubmed/17663857 (abre nova janela)

Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. (abre nova janela)

Rohde JM, Dimcheff DE, Blumberg N, Saint S, Langa KM, Kuhn L, Hickner A, Rogers MA.

Fonte‎: JAMA 2014;311(13):1317-26.

Indexado‎: PubMed 24691607

DOI‎: 10.1001/jama.2014.2726

https://www.ncbi.nlm.nih.gov/pubmed/24691607 (abre nova janela)

Impact of more restrictive blood transfusion strategies on clinical outcomes: a meta-analysis and systematic review. (abre nova janela)

Salpeter SR, Buckley JS, Chatterjee S.

Fonte‎: Am J Med 2014;127(2):124-131.e3.

Indexado‎: PubMed 24331453

DOI‎: 10.1016/j.amjmed.2013.09.017

https://www.ncbi.nlm.nih.gov/pubmed/24331453 (abre nova janela)

Heart transplant in Jehovah's Witness patients: a case-control study. (abre nova janela)

Sander S, Singer-Englar T, Nishihara K, Esmailian F, Patel JK, Kobashigawa JA, Kittleson MM

Fonte‎: J Heart Lung Transplant 2021;40(7):575-9.

Indexado‎: PubMed 33839007

DOI‎: 10.1016/j.healun.2021.03.014

https://www.ncbi.nlm.nih.gov/pubmed/33839007 (abre nova janela)

Perioperative anemia and transfusions and late mortality in coronary artery bypass patients. (abre nova janela)

Schwann TA, Vekstein AM, Engoren M, Grau-Sepulveda M, O'Brien S, Engelman D, Lobdell KW, Gaudino MF, Salenger R, Habib RH

Fonte‎: Ann Thorac Surg 2023 115(3):759-69.

Indexado‎: PubMed 36574523

DOI‎: 10.1016/j.athoracsur.2022.11.012

https://pubmed.ncbi.nlm.nih.gov/36574523/ (abre nova janela)

The safety and efficacy of "bloodless" cardiac surgery. (abre nova janela)

Shander A, Moskowitz D, Rijhwani TS.

Fonte‎: Semin Cardiothorac Vasc Anesth 2005;9(1):53-63.

Indexado‎: PubMed 15735844

DOI‎: 10.1177/108925320500900106

https://www.ncbi.nlm.nih.gov/pubmed/15735844 (abre nova janela)

Comparisons of cardiac surgery outcomes in Jehovah's versus non-Jehovah's Witnesses. (abre nova janela)

Stamou SC, White T, Barnett S, Boyce SW, Corso PJ, Lefrak EA.

Fonte‎: Am J Cardiol 2006;98(9):1223-5.

Indexado‎: PubMed 17056333

DOI‎: 10.1016/j.amjcard.2006.05.055

https://www.ncbi.nlm.nih.gov/pubmed/17056333 (abre nova janela)

Outcomes in cardiac surgery in 500 consecutive Jehovah's Witness patients: 21 year experience. (abre nova janela)

Vaislic CD, Dalibon N, Ponzio O, Ba M, Jugan E, Lagneau F, Abbas P, Olliver Y, Gaillard D, Baget F, Sportiche M, Chedid A, Chaoul G, Maribas P, Dupuy C, Robine B, Kasanin N, Michon H, Ruat JM, Habis M, Bouharaoua T.

Fonte‎: J Cardiothorac Surg 2012;7:95.

Indexado‎: PubMed 23013647

DOI‎: 10.1186/1749-8090-7-95

https://www.ncbi.nlm.nih.gov/pubmed/23013647 (abre nova janela)

Outcome of Jehovah's Witnesses after adult cardiac surgery: systematic review and meta-analysis of comparative studies. (abre nova janela)

Vasques F, Kinnunen EM, Pol M, Mariscalco G, Onorati F, Biancari F.

Fonte‎: Transfusion 2016;56(8):2146-53.

Indexado‎: PubMed 27197962

DOI‎: 10.1111/trf.13657

https://www.ncbi.nlm.nih.gov/pubmed/27197962 (abre nova janela)

Transfusion strategies for acute upper gastrointestinal bleeding. (abre nova janela)

Villanueva C, Colomo A, Bosch A, Concepción M, Hernandez-Gea V, Aracil C, Graupera I, Poca M, Alvarez-Urturi C, Gordillo J, Guarner-Argente C, Santaló M, Muñiz E, Guarner C.

Fonte‎: N Engl J Med 2013;368(1):11-21.

Indexado‎: PubMed 23281973

DOI‎: 10.1056/NEJMoa1211801

https://www.ncbi.nlm.nih.gov/pubmed/23281973 (abre nova janela)