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重度乙型地中海貧血(兒科)

經由藥物誘導體內胎兒血紅蛋白的合成

羥基脲(Hydrea)療法

Efficacy of hydroxyurea in providing transfusion independence in β-thalassemia. (開啟新視窗)

Ansari SH, Shamsi TS, Ashraf M, Perveen K, Farzana T, Bohray M, Erum S, Mehboob T.

出處‎: J Pediatr Hematol Oncol 2011;33(5):339-43.

檢索‎: PubMed 21602718

DOI碼‎: 10.1097/MPH.0b013e31821b0770

https://www.ncbi.nlm.nih.gov/pubmed/21602718 (開啟新視窗)

Gγ-Xmn I polymorphism: a significant determinant of β-thalassemia treatment without blood transfusion. (開啟新視窗)

Ansari SH, Shamsi TS, Munzir S, Khan MT, Erum S, Perveen K, Farzana T, Ashraf M, Mehboob T, Moinuddin M.

出處‎: J Pediatr Hematol Oncol 2013;35(4):e153-6.

檢索‎: PubMed 23389500

DOI碼‎: 10.1097/MPH.0b013e31827e8662

https://www.ncbi.nlm.nih.gov/pubmed/23389500 (開啟新視窗)

Efficacy of hydroxyurea (HU) in reduction of pack red cell (PRC) transfusion requirement among children having beta-thalassemia major: Karachi HU trial (KHUT). (開啟新視窗)

Ansari SH, Shamsi TS, Siddiqui FJ, Irfan M, Perveen K, Farzana T, Panjwani VK, Yousuf A, Mehboob T.

出處‎: J Pediatr Hematol Oncol 2007;29(11):743-6.

檢索‎: PubMed 17984691

DOI碼‎: 10.1097/MPH.0b013e318157fd75

https://www.ncbi.nlm.nih.gov/pubmed/17984691 (開啟新視窗)

Hydroxyurea can eliminate transfusion requirements in children with severe beta-thalassemia. (開啟新視窗)

Bradai M, Abad MT, Pissard S, Lamraoui F, Skopinski L, de Montalembert M.

出處‎: Blood 2003;102(4):1529-30.

檢索‎: PubMed 12702505

DOI碼‎: 10.1182/blood-2003-01-0117

https://www.ncbi.nlm.nih.gov/pubmed/12702505 (開啟新視窗)

Decreased transfusion needs associated with hydroxyurea therapy in Algerian patients with thalassemia major or intermedia. (開啟新視窗)

Bradai M, Pissard S, Abad MT, Dechartres A, Ribeil JA, Landais P, de Montalembert M.

出處‎: Transfusion 2007;47(10):1830-6.

檢索‎: PubMed 17880608

DOI碼‎: 10.1111/j.1537-2995.2007.01399.x

https://www.ncbi.nlm.nih.gov/pubmed/17880608 (開啟新視窗)

Genotype-phenotype relationship of patients with β-thalassemia taking hydroxyurea: a 13-year experience in Iran. (開啟新視窗)

Karimi M, Haghpanah S, Farhadi A, Yavarian M.

出處‎: Int J Hematol 2012;95(1):51-6.

檢索‎: PubMed 22180324

DOI碼‎: 10.1007/s12185-011-0985-6

https://www.ncbi.nlm.nih.gov/pubmed/22180324 (開啟新視窗)

A randomised double-blind placebo-controlled clinical trial of oral hydroxyurea for transfusion-dependent β-thalassaemia. (開啟新視窗)

Yasara N, Wickramarathne N, Mettananda C, Silva I, Hameed N, Attanayaka K, Rodrigo R, Wickramasinghe N, Perera L, Manamperi A, Premawardhena A, Mettananda S

出處‎: Sci Rep. 2022;12(1):2752.

檢索‎: PubMed 35177777

DOI碼‎: 10.1038/s41598-022-06774-8

https://pubmed.ncbi.nlm.nih.gov/35177777/ (開啟新視窗)

Response to hydroxyurea treatment in Iranian transfusion-dependent beta-thalassemia patients. (開啟新視窗)

Yavarian M, Karimi M, Bakker E, Harteveld CL, Giordano PC.

出處‎: Haematologica 2004;89(10):1172-8.

檢索‎: PubMed 15477200

https://www.ncbi.nlm.nih.gov/pubmed/15477200 (開啟新視窗)

Hydroxyurea therapy in 49 patients with major beta-thalassemia. (開啟新視窗)

Zamani F, Shakeri R, Eslami SM, Razavi SM, Basi A.

出處‎: Arch Iran Med 2009;12(3):295-7.

檢索‎: PubMed 19400608

https://www.ncbi.nlm.nih.gov/pubmed/19400608 (開啟新視窗)

基因重組紅血球生成素(單獨給予或合併其他製劑)

Use of hydroxyurea and recombinant erythropoietin in management of homozygous ß⁰ thalassemia. (開啟新視窗)

Kohli-Kumar M, Marandi H, Keller MA, Guertin K, Hvizdala E.

出處‎: J Pediatr Hematol Oncol 2002;24(9):777-8.

檢索‎: PubMed 12468925

https://www.ncbi.nlm.nih.gov/pubmed/12468925 (開啟新視窗)

其他製劑

Fetal globin gene inducers: novel agents and new potential. (開啟新視窗)

Perrine SP, Castaneda SA, Chui DH, Faller DV, Berenson RJ, Siritanaratku N, Fucharoen S.

出處‎: Ann N Y Acad Sci 2010;1202:158-64.

檢索‎: PubMed 20712788

DOI碼‎: 10.1111/j.1749-6632.2010.05593.x

https://www.ncbi.nlm.nih.gov/pubmed/20712788 (開啟新視窗)